AMB Volume 42, Issue 3, 2026 Pages 483-498 https://doi.org/10.59393/amb26420312
From Antarctica to Antibiotics: Antibacterial Potential of Filamentous Fungi from Livingston Island
Dishliyska V., Stoyancheva G., Yovchevska L., Abrashev R., Miteva-Staleva J., Gerginova M., Spasova B., Gocheva Y., Angelova M., Krumova E.
Microbial resistance represents one of the most pressing challenges in contemporary medicine and biotechnology, driving the ongoing search for novel bioactive compounds with unique antimicrobial properties. Extreme environments and their associated extremophilic microorganisms constitute a promising reservoir of such metabolites. Among them, Antarctic filamentous fungi have evolved specialized adaptive strategies that enable survival under severe environmental constraints, including the biosynthesis of structurally diverse bioactive molecules.
The present study investigates the potential of filamentous fungi isolated from soil samples collected on Livingston Island, Antarctica, to produce antibacterial metabolites. Notably, 75% of the tested strains exhibited antibacterial activity. The most active isolate was identified as Talaromyces pinophilus II 13. Metabolomic profiling suggested the presence of β-lactam-related metabolites and other antimicrobial secondary metabolites, underscoring its considerable biotechnological and pharmaceutical potential.
Keywords: antarctic, filamentous fungi, antibacterial substances
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