AMB Volume 41, Issue 2, 2025 Pages 140-147 https://doi.org/10.59393/amb25410202
Pseudomonas aeruginosa Resistance – A Challenge in the Treatment of Healthcare-Associated Infections
Bekyarov P., Mihaylova S.
Infections caused by Pseudomonas aeruginosa pose a significant threat to human health and are the main contributors to mortality in the United States, Japan, and Europe. These pathogens are the leading causes of nosocomial infections, particularly in immunosuppressed patients. P. aeruginosa develops resistance to a wide range of antibiotics through various mechanisms, including efflux pumps, chromosomal mutations, and the production of beta-lactamases. The high heterogeneity among different strains and the ability to code for a diverse range of proteins make P. aeruginosa exceptionally difficult to treat. These characteristics complicate the development of effective therapeutic agents. New therapies are being explored to combat resistance, including antibiotic combinations and bacteriophages, which show promising results. Despite advances in research, infections caused by P. aeruginosa remain a significant social and health problem, requiring urgent measures to effectively manage antibiotic resistance effectively.
Keywords: Pseudomonas aeruginosa, antibiotic resistance, hospital-acquired infections (HAI), novel approaches, ceftolozane-tazobactam, ceftazidime-avibactam, phage therapy
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