AMB Volume 40, Issue 2, 2024 Pages 142-152 https://doi.org/10.59393/amb24400202
Candida auris: a Multidimensional Overview of a Rising Global Fungal Threat
Tsitou V-M., Rallis D., Tsekova M., Yanev N.
This review offers a multidimensional analysis of Candida auris, a significant fungal pathogen emerging globally, challenging healthcare systems. Discovered recently, C. auris draws attention due to its rapid spread, multidrug resistance, and high morbidity and mortality rates, particularly in immunocompromised individuals. Its taxonomic classification within the Metschnikowiaceae family sets it apart from common Candida species. We discuss C. auris’s phenotypic traits, including its survival in extreme conditions and unique morphology, and delve into genomic insights like ploidy switching and clade-specific variations. Its epidemiology demonstrates adaptability, with environmental isolates found in diverse ecosystems, indicating broader ecological impacts. The review explores C. auris’s presence in European healthcare environments, emphasizing its role in nosocomial infections. Diagnosing C. auris is challenging; traditional methods are limited, highlighting the need for advanced molecular diagnostics for accurate identification. A key focus is C. auris’s antifungal resistance, detailing resistance mechanisms to major antifungal classes and efforts toward developing effective treatments. Finally, the review stresses the importance of infection control and prevention strategies in healthcare settings, underscoring the need for comprehensive measures to mitigate the spread of this formidable pathogen.
Keywords: Candida auris, antifungal resistance, nosocomial infections, epidemiology, pathogen genomics, infection control and prevention
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